What is the composition and form of Zolpidem?

The drug is produced in tablets, in addition to auxiliary compounds is present and the active substance, represented by zolpidem in the amount of ten milligrams.

Tablets sold by prescription. They can be stored for three years from the date of issue, after which their further use is recommended to be discarded. It is impossible for children to use the medication, respectively, it must be removed to an inaccessible place.

What is the effect of Zolpidem?

The drug Zolpidem has a hypnotic effect, the drug belongs to the group of so-called imidazopyridines. The drug has a sedative effect, stimulates the benzodiazepine receptors, shortens the period of sleep, reduces nighttime awakening, in addition, the duration of sleep increases, as well as improves its quality. During the day, does not cause drowsiness.

The active substance of the drug is rapidly absorbed from the gastrointestinal tract. The time of maximum concentration varies from thirty minutes to three hours. Bioavailability does not exceed 70%. Protein binding – 92%. It is metabolized to form three metabolites in an inactive form, which are excreted by the kidneys and with a stool.

What are the indications for zolpidem use?

The drug Zolpidem is indicated for use in sleep disorders, in particular, in the difficult process of falling asleep, as well as during night awakenings.

What are the contraindications of Zolpidem use?

I will list the conditions when the drug Zolpidem is contraindicated for use:

  • Do not prescribe medication until the age of eighteen;
  • With respiratory and hepatic failure;
  • With lactation;
  • With nighttime respiratory arrest;
  • During pregnancy;
  • With malabsorption syndrome, with hereditary lactose intolerance;
  • In case of hypersensitivity to drug substances.

With care, Zolpidem is used in severe myasthenia, in the depressed state, in alcoholism and drug addiction, as well as in other addictions.

What are the use and dosage of Zolpidem?

Zolpidem tablets are taken orally in the amount of ten milligrams immediately before bedtime, with a small amount of water washed down with medicine. In elderly patients, as well as in violation of the liver, the drug is prescribed with a dose of 5 mg. The maximum daily dosage is no more than 10 mg. Therapeutic course should not last more than a month.


With an overdose of Zolpidem medication in a patient, consciousness is disturbed even to a comatose state, in addition, a decrease in blood pressure is added, and respiratory depression is not excluded.

In this case, in the first hour after an overdose of the drug, it is necessary to provoke vomiting, after which the patient is recommended to take several tablets of activated carbon, in addition, the patient is given the necessary set of symptomatic measures.

Flumazenil can serve as an antidote, it belongs to the antagonists of the so-called benzodiazepine receptors, it should be remembered that the use of this tool does not exclude the development of seizures, especially in people suffering from epilepsy. Dialysis does not give the desired effect.

What are the side effects of zolpidem?

Zolpidem tablets are usually well tolerated, but in some cases side effects are not excluded, which manifest themselves in the following symptoms: drowsiness, a characteristic feeling of intoxication, a headache occurs, insomnia may increase, dizziness, hallucinations, irritability occur, nightmares occur, there may be confusion, aggressiveness, increased excitability, in addition, drug dependence, decreased libido, in old age there are frequent drops, and also  violation of gait.

Among other manifestations, there are violations of the digestive system, which is usually manifested by liquid stool, nausea, vomiting, abdominal pain, and the increase in liver enzyme activity is determined by laboratory.

Other undesirable effects: muscular weakness develops, double vision is possible, a feeling of tiredness is characteristic, besides, from the skin some negative manifestations in the form of itching and rash are also possible, and there may also be urticaria, excessive sweating. In some situations, developing angioedema.

Special instructions

When using the drug Zolpidem in a patient, the development of mental and behavioral negative reactions is not excluded, especially the risk of their development is greater in elderly people. When they occur, the use of the medication should be temporarily discontinued.

The use of tablets in the elderly increases the risk of a pronounced muscle relaxant, as well as a sedative effect, therefore, the medicine is prescribed with caution. During the period of treatment you need to refrain from driving.



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